R92.00 incl VAT
The landscape of type 2 diabetes is shifting from a monolithic diagnosis toward a nuanced spectrum of metabolic profiles. Our live session will explore two pillars of modern diabetology: the fundamental role of beta cell dysfunction and the emerging science of precision subtyping. Recent research confirms that early abnormalities in insulin secretion, rather than a mere reduction in beta-cell mass, drive the initial transition to hyperglycemia. This functional decline is a dynamic process influenced by genetics, glucolipotoxicity and inter-organ crosstalk, yet it also offers a window for potential remission through targeted interventions.
However, moving toward “precision medicine” requires more than just identifying subtypes like severe insulin-deficient (SIDD) or insulin-resistant (SIRD) diabetes. It requires acknowledging the inherent classification uncertainty. Using novel tools like Normalized Relative Entropy (NRE), clinicians can now quantify how well an individual fits a specific subtype. Recognizing this uncertainty is not a failure of diagnostics but an inclusive advancement; it ensures we do not force diverse patient realities into rigid clinical boxes.
Philosophically, diabetes is not a static state but a narrative of biological resilience and adaptation. By embracing both the molecular “how” of the beta cell and the statistical “maybe” of our classifications, we can provide care that is as individual as the patients we serve.
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